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KMID : 0380620200520050441
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Korean Journal of Food Science and Technology
2020 Volume.52 No. 5 p.441 ~ p.449
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Inhibitory effect of Allium macrostemon extracts on adipogenesis of 3T3-L1 preadipocytes
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Lee Joo-Yeon
Jeong Ye-Ju
Kim Jin-A
Kim Choon-Young
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Abstract
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The aim of this study was to compare the biological activities of whole-plant (WAE), bulb (BAE), and leaf (LAE) extracts of Allium macrostemon. The antioxidant activities, total polyphenol contents, and anti-adipogenic activities of WAE and LAE were superior to those of BAE, whereas the biological effects of WAE and LAE were similar.
Therefore, the effect of LAE on adipogenesis was further investigated. Treatment of preadipocytes with LAE at 100 g/mL resulted in the inhibition of intracellular lipid accumulation by 49.64%. Consistent with this result, quantitative reverse transcription-PCR showed that LAE treatment decreased the gene expressions of CCAAT/enhancer-binding protein beta (C/ EBPβ), peroxisome proliferator-activated receptor gamma (PPARγ), C/EBPα and stearoyl-CoA desaturase 1 (SCD1). Thus, LAE attenuates the adipogenesis of preadipocytes by suppressing the expression of adipogenic and lipogenic genes. These results suggest that LAE can be potentially useful as a functional ingredient to prevent obesity in the food industry.
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KEYWORD
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anti-obesity, adipocyte differentiation, Allium macrostemon,, long-stamen chive, antioxidant activity
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